The Incidence of Mosaicism for Individual Chromosome in Human Blastocysts Is Correlated With Chromosome Length

Mosaicism, known as partial aneuploidies, mostly originates from mitotic errors during the post-zygotic stage; it consists of different cell lineages within a human embryo. The incidence mosaicism has not been shown to correlate with maternal age, and its correlation individual chromosome characteristics well investigated. In this study, results preimplantation genetic testing for aneuploidy (PGT-A) derived 4,036 blastocysts (930 IVF couples) were collected 2015 2017. Via next-generation sequencing comprehensive screening, embryo ploidy was identified aneuploid, mosaic, euploid. Total classified into two categories: “mosaic euploid/aneuploidy” (with mosaic between 20 80%) aneuploidy” (a uniformly abnormal superimposed aneuploidies). Frequency analyzed according function chromosomal lengths, which divides involved chromosomes three groups: group A (156–249 Mb), B (102–145 C (51–90 Mb). show that more frequent in than (A: 23.7%, B: 35.1, 41.2%, p < 0.0001), while [(Mosaic euploid/aneuploid) A: 14.6%, 12.4%, C: 9.9%, 0.0001; (mosaic aneuploid) 21.3%, 22.9%, 18.9%, (Total mosaicism) 35.9%, 35.3%, 28.8%, 0.0001]. significantly higher frequency on shorter (< 90 longer (> 100 length association did reach significance patients advanced age (≥ 36 years), chromosome-specific rate, highest prevalence 14 (5.8%), 1 (5.7%), 9 (5.6%). Although observed via comparison, there may be affecting mechanisms other length. Eventually, twenty cryotransfers resulted six live births. No significant transfer outcomes length; however, analysis limited by small sample size.